The truth is that many grocery store chains will operate with a reduced hours schedule this year — after all, employees want to celebrate the holiday, too. Those hours depend on the exact chain in question and may even vary from store to store, so you'll want to double-check by calling ahead or looking online before trekking out to one of these grocery stores.
Open grocery stores on Thanksgiving Day include (but aren't necessarily limited to) Albertsons, Food Lion, Kroger, Ralphs, Rite-Aid, Safeway, Hannaford, H-E-B, Sprouts Farmers Market, Hy-Vee, Wawa, Winn-Dixie, Wegmans, and Whole Foods. It's worth noting that Kroger's pharmacies will not be open on Thanksgiving Day, however, even though the grocery store itself will be. Your local Piggly Wiggly may also be open, but these stores are independently owned and can have widely varying hours, so it's doubly important that you check with your local Piggly Wiggly store first.
If you only need a staple ingredient or two, it might be worth stopping in at a CVS or Rite Aid convenience store instead of your local grocery. These drug stores are stocked with some essential food items (though probably not things like whole turkeys), but they will be open for limited hours on the holiday, too.
