And I wonder if certain items that seem innocuous are actually addictive, or could become addictive with just a few small chemical changes. Like, are Chansey's eggs or Miltank's milk really delicious/nutritious, or is there more to it than meets the eye? Maybe these items do much more to people's body than they think, but because people feel good after using them, they assume that these items do good to their body, as well.
And then of course there are the drug-like effects you can experience without taking drugs at all. Stantler was mentioned, and I immediately thought about Gothitelle when that idea was mentioned, since you can see the stars through its distortion of space. And then imagine going through one of these space-distortion experiences while under the influence of drugs... !
Also, can drugs have an effect on Pokémon? What is it about Slowbro's tail that makes Shellder not want to let go? And are the toxins that secrete from Shellder do more than just make Slowking more intelligent?
So many questions.